Journal of Medicinal Chemistry

Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships

Truncated Autoinducing Peptides as Antagonists ofStaphylococcus lugdunensisQuorum Sensing

Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors

Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance

Design, Synthesis, and Structure-Activity Relationships of 1-,3-,8-, and 9-Substituted-9-deazaxanthines at the Human A2BAdenosine Receptor

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective a1A-Adrenoceptor Antagonists

Design, Synthesis, and Biological Evaluation of a Series of 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and the Reverse Transcriptase RNase H Domain

Design, Synthesis, and Binding Affinities of Potential Positron Emission Tomography (PET) Ligands for Visualization of Brain Dopamine D3Receptors

Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Design and Synthesis of Potent Quinazolines as Selective beta-Glucocerebrosidase Modulators

Crystallographic Investigation of the Inhibition Mode of a VIM-2 Metallo-beta-lactamase fromPseudomonas aeruginosaby a Mercaptocarboxylate Inhibitor